Schedule Your Appointment in Honor of Isabella’s Birthday
March 6 – 9, 2026 | Charlotte or Ballantyne Donor Centers
Say “ISF” to ensure $10 is donated back
Saturday, March 21, 2026 | 12:00 – 3:00pm | Tipsy Pickle
Tickets Are Live!
Saturday, February 28, 2026 | 7:00 pm | The Revelry North End
Sponsorships Available Now
October 22, 2026 | 7:00 pm | The Revelry North End
Preserving Dreams at MUSC & Levine
50¢ from every ice cream scoop benefits ISF
Who We Are
The Isabella Santos Foundation (ISF) is a 501(c)(3) nonprofit dedicated to eradicating rare pediatric cancer.
Since 2007, ISF has funded groundbreaking research, clinical trials and survivorship programs focused on underfunded cancers—bringing hope, healing and better outcomes to kids around the world. Inspired by Isabella’s legacy, we believe every child deserves a chance to survive and thrive.
RAISED SINCE 2007
Our Impact
From humble beginnings, raising $7,000 in the first year, ISF has contributed millions to advance research, treatment and support for families battling rare pediatric cancers.
Today, ISF remains steadfast in its dedication to eradicating the devastating impact of these diseases, all while honoring the legacy of Isabella Santos, a courageous cancer warrior who lost her fight to neuroblastoma in 2012.
Fueled by Isabella ♥ Years of Impact
2005
Isabella Santos is born.
2007
Isabella is diagnosed with stage 4 neuroblastoma at age 2.
2008
1st Annual ISF 5K for Kids Cancer is held, raising $7,000.
2012
Isabella Santos passes away at age 7 after five relapses.
2013-2014
ISF expands its fundraising efforts to support early-stage research for all rare pediatric cancers.
2014-2015
Continues to launch new programs providing critical support for families in Charlotte, NC.
2016
Funds national initiatives, including Frontline MIBG Therapy Trial, Circulating Tumor DNA Project, HU348 Clinical Trial, SADA Drug Delivery Platform & Project Every Child Study.
2017
Funds DFMO Pilot Clinical Trial led by Dr. Giselle Sholler.
2018
The ISF MIBG Treatment Suite opens at Levine Children’s Hospital – 1 of only 20 in the U.S. – after making a $1M investment.
2019
ISF commits $5M to fund the ISF Rare & Solid Tumor Program, the first of its kind in the region, at Levine Children’s Hospital.
2019
The Isabella Santos OneBlood Donation Center opens in Ballantyne.
2020
ISF Rare & Solid Tumor Program launches at Levine Children’s.
2020
World-renowned researcher Dr. Giselle Sholler joins the ISF Rare & Solid Tumor program.
2020
Solid tumor patient volume doubles at Levine Children’s Hospital.
2021
ISF’s cumulative impact surpasses $13M and makes its first $1M donation.
2021
The Live My Dreams Program launches at Levine Children’s Hospital.
2021
Funds the TINKS Trial with Live Like Madison and Move for Jenn and the P.E.A.C.H. Protocol for neuroblastoma/DIPG clinical trials.
2022
ISF’s cumulative impact surpasses $14M, and donates $1.42M to support over 88 local families.
2022
Expands the PEACH Protocol to include an osteosarcoma arm and commits to fund all precision medicine within the program.
2022
Funds new roles at Levine Children’s Hospital, including pediatric cancer research nurses, social workers, nutritionists and more.
2023
ISF’s cumulative impact surpasses $15M, supporting families from 20+ countries who travel to Charlotte for care.
2024
ISF’s cumulative impact surpasses $16M and launches the TORCH Initiative, setting a bold $2M annual goal.
2025
ISF announces six hospital recipients to receive TORCH funding for clinical research, basic science and survivorship programs.
2025
Annual Gala raises $853,000 — the highest to date — and ISF media exposure reaches 1.34 million views.
2026 & Beyond
ISF continues expanding TORCH partnerships, deepening research investment and uniting more donors to transform outcomes for rare cancer heroes.
Signature Events
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Thank You To Our
2025 Sustaining Sponsors
